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Personalized B2B Cold Email Sequence with GPT-4 + Gmail Auto-Reply Detection

by Peyrichou MaximeUpdated: Last update 3 days agoSource: n8n.io
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Getting Started

🎯 Automated B2B Cold Email Sequence with AI Personalization

Stop manually sending follow-ups. This workflow automates your entire cold email outreach with AI-powered personalization, smart scheduling, and automatic reply detection.

✨ What It Does

This workflow sends a perfectly-timed 3-email sequence to B2B prospects with:

  • AI-generated personalized emails adapted to each prospect's sector, company size, and role
  • Smart scheduling : Only sends Tuesday/Wednesday/Thursday at optimal times (~9AM with randomization)
  • Bilingual support : Auto-detects French or English prospects
  • Reply detection : Automatically stops the sequence when someone replies
  • Spam prevention : Randomized sending times, professional intervals
  • Full tracking : Updates Google Sheets with send status and reply detection
  • Slack notifications : Get alerted immediately when a hot lead responds

📊 Expected Results

Based on real usage:

  • 10-15% reply rate (vs 3-8% for generic cold emails)
  • 2-5 hot leads per 30 prospects contacted
  • 90% time saved vs manual outreach
  • Professional delivery that preserves sender reputation

🎬 How It Works

  1. Add prospect to Google Sheet (Email, Name, Company, etc.)
  2. Workflow triggers automatically on new row
  3. Time planning calculates optimal send dates (Tue/Wed/Thu only)
  4. Email 1 (J0): AI generates introduction with value prop (80-120 words)
  5. Wait 3 days
  6. Email 2 (J+3): Follow-up with new angle or case study (70-90 words)
  7. Wait 4 days
  8. Email 3 (J+7): Final soft close, respectful exit (60-100 words)
  9. Reply detection : Monitors Gmail → marks prospect "hot" → Slack alert → stops sequence

🚀 Perfect For

  • Sales teams doing B2B cold outreach
  • Agencies prospecting new clients
  • SaaS founders building their pipeline
  • Consultants/freelancers doing business development
  • Anyone tired of manual follow-ups and low response rates

⚙️ Requirements

Required:

  • Google Sheets (free)
  • Gmail account (free)
  • OpenAI API key (~$0.50 per 100 emails)

Optional:

  • Slack (for notifications)

n8n version: Compatible with n8n 1.0+